CHMY 526 — Solution NMR Spectroscopy:Practical Applications to the Structural Determination of Small Molecules: 3 Credits (3 Lec)
(F, Sp) This course integrates hands-on practical sessions using the NMR spectrometers of MSU Core NMR facility, with instructor lectures. The goal is to enable students to master the canonical NMR experiments employed for structural characterization of small molecules and measurements of molecular dispersion and reaction kinetics. Students will be paired to work together on the spectrometers (300 MHz, 400 MHz, 500 MHz, or 600 MHz NMRs) and will learn, by conducting in real time, a range of commonly used NMR experiments for small molecule characterization and reaction kinetics. The students will gain practical knowledge on how to set-up different NMR experiments and how to run the NMR spectrometers. NMR experiments that students will become proficient in, will range from simple 1D 1H NMR to more sophisticated 2D heteronuclear (1H, 13C, 15N) experiments including HSQC, HMBC, 2D-NOESY, TOCSY, J-resolved spectroscopy, among others. Students should have some familiarity with analytical methods, spectroscopy, and elements of physical chemistry. Students should have a background in basic chemistry, including: the atoms, the elements and the periodic table; the structure of organic molecules (functional groups, stereochemistry); as well as in basic physical chemistry, including some basic knowledge about the spectroscopy (energy levels, photon, frequency).